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However, the therapeutic effectiveness of endogenous stem cell infiltration is often hindered by the presence of accumulated reactive oxygen species (ROS) and inadequate oxygen levels 21,22

Statistical significance vs clinical significance: Small changes within measurement variability (1-2 letters visual acuity) not meaningful

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As the first ferroptosis inhibitor to enter preclinical ophthalmic development, Fer-1 eye drops were originally limited by the drugs inherent hydrophobicity

Additionally, it is important to note that NR readily degrades in human and rodent plasma, and NMN degrades in human plasma, suggesting low systemic stability of the molecules when administered orally 68,124,125